Optimization of warfarin dose by population-specific pharmacogenomic algorithm
نویسندگان
چکیده
منابع مشابه
Effect of patient-specific factors on weekly warfarin dose
OBJECTIVE To determine the influence of various patient-specific factors, use of concomitant medications, and weekly vitamin K intake on total weekly warfarin maintenance dose (TWD). METHODS Information collected, via retrospective chart review, included TWD, general demographics, vitamin K consumption, target INR range, use of alcohol, tobacco, and cytochrome P450 (CYP)-inducing medications,...
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چکیده-پخش بار بهینه به عنوان یکی از ابزار زیر بنایی برای تحلیل سیستم های قدرت پیچیده ،برای مدت طولانی مورد بررسی قرار گرفته است.پخش بار بهینه توابع هدف یک سیستم قدرت از جمله تابع هزینه سوخت ،آلودگی ،تلفات را بهینه می کند،و هم زمان قیود سیستم قدرت را نیز برآورده می کند.در کلی ترین حالتopf یک مساله بهینه سازی غیر خطی ،غیر محدب،مقیاس بزرگ،و ایستا می باشد که می تواند شامل متغیرهای کنترلی پیوسته و گ...
A Clustering Approach by SSPCO Optimization Algorithm Based on Chaotic Initial Population
Assigning a set of objects to groups such that objects in one group or cluster are more similar to each other than the other clusters’ objects is the main task of clustering analysis. SSPCO optimization algorithm is anew optimization algorithm that is inspired by the behavior of a type of bird called see-see partridge. One of the things that smart algorithms are applied to solve is the problem ...
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Ms Rhee and Dr Smith are from the University of Kentucky College of Pharmacy, and Drs Walsh, Lewis, and Davis are from UK Healthcare, Lexington, Kentucky. Ms Rhee and Drs Walsh, Lewis, Davis, and Smith have no relevant fi nancial relationships to disclose. Correspondence should be addressed to: Kelly M. Smith, PharmD, BCPS, FASHP, FCCP, University of Kentucky College of Pharmacy, 789 S Limeston...
متن کاملEffects of fixed low-dose warfarin, aspirin-warfarin combination therapy, and dose-adjusted warfarin on thrombogenesis in chronic atrial fibrillation.
BACKGROUND AND PURPOSE Recent clinical trials have established that adjusted-dose warfarin (international normalized ratio [INR] 2.0 to 3.0) is highly effective in the reduction of ischemic stroke in patients with nonvalvular atrial fibrillation (AF). We hypothesized that the introduction of fixed low-dose warfarin alone or in combination with aspirin (300 mg) could normalize hemostatic markers...
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ژورنال
عنوان ژورنال: The Pharmacogenomics Journal
سال: 2011
ISSN: 1470-269X,1473-1150
DOI: 10.1038/tpj.2011.4